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JournalSam Lee, M.D., Ph.D.
Sam Lee, M.D., Ph.D.

Sam Lee, M.D., Ph.D.

Editorial Board MemberFounding Member

College of Doctoral Studies Grand Canyon University, USA

Editorial Vision

"As an Editorial Board Member for Scholarly Open: Medicine, I am dedicated to advancing evidence-based healthcare, health outcomes research, and healthcare quality improvement. I welcome high-impact research evaluating clinical effectiveness, healthcare operations, predictive analytics, and evidence synthesis."

Status

Accepting Submissions

Ready to review manuscripts

Avg. Turnaround

21 Days

From assignment to review completion

Review Standard

Rigorous Double-Blind

Ensuring evidence-based standards

Editorial Mandate

Managed Sections

Healthcare Administration & QualityEvidence-Based MedicineHealth Services ResearchClinical Operations & Analytics

Biography

Dr. Sam Lee, MD, PhD, DHA Candidate, is an accomplished physician-scientist, healthcare administrator, and evidence-based medicine researcher with over 30 years of clinical, academic, and biomedical research experience across the United States, China, and international healthcare systems. He currently serves as Principal Investigator at Grand Canyon University and is the Founder and Chief EBM Scientist at the Applied Clinical EBM Institute (ACEI) in Honolulu, Hawaii.

Currently a Doctor of Health Administration (DHA) candidate at the College of Doctoral Studies, Grand Canyon University (Phoenix, AZ / Honolulu, HI), Dr. Lee's doctoral research focuses on hospital-level organizational factors associated with risk-standardized mortality rates among U.S. acute care hospitals using publicly available CMS datasets.

Dr. Lee earned his M.D. equivalent and completed surgical specialization at Shanghai Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine (SJTUSM), practicing as a licensed General Surgeon for over ten years. He holds a Master of Science (M.Sc.) and a Ph.D. in Surgery (Medical Sciences) from SJTUSM. He conducted postdoctoral biomedical research as an NIH Postdoctoral Fellow and Research Scholar at the National Institutes of Health (NIH / NICHD / NIAID) in Bethesda, MD, and served as a Research Associate at St. Jude Children's Research Hospital and the University of Tennessee Health Science Center (UTHSC).

His broad research portfolio spans evidence-based medicine (EBM), health services research, quantitative data analysis, healthcare quality improvement, cancer biology, epigenetics, and neurogenomics. Dr. Lee co-discovered Kynurenine Aminotransferase III (KAT III) and pioneered the first publicly searchable RNA-seq transcriptomic dataset for BXD mouse brains in the UCSC Genome Browser.

Selected Publications

Author Name Note:Due to a legal name change, publications appear under his former name ZhengSheng Li and are indexed as Li, Z. or Li, D. Both names refer to the same author.

A transposon in COMT generates mRNA variants and causes widespread expression and behavioral differences among mice

PLoS ONE2010

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Joint mouse-human phenome-wide association to test gene function and disease risk

Nature Communications2016

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Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting Topoisomerases

Yeast as a Tool in Cancer Research (Springer)2007

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A promoter polymorphism in the Per3 gene is associated with alcohol and stress response

Translational Psychiatry2012

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Academic Roadmap

1995

M.Sc. in Surgery

Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Awarded Outstanding Master's Thesis Award.

1998

Ph.D. in Surgery (Medical Sciences)

Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Awarded Ph.D. Candidate Scholarship & NSFC Grant.

1998-2000

General Surgeon & Assistant Professor

Shanghai Institute of Digestive Surgery, Shanghai Ruijin Hospital. Over 10 years of clinical surgical practice.

2000-2002

NIH Postdoctoral Fellow

National Institutes of Health (NIH), Bethesda, MD, USA. U.S.–China Exchange Scholar in cancer biology and epigenetics.

2002-2005

NIH Research Scholar Fellowship

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA.

2005-2007

Research Associate in Molecular Pharmacology

St. Jude Children's Research Hospital, Memphis, TN, USA. Investigated anticancer agent mechanisms targeting topoisomerases.

2007-2016

Research Associate in Genetics & Neurobiology

University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA. Created BXD mouse brain RNA-seq dataset for UCSC Genome Browser.

2023-Present

Founder & Chief EBM Scientist

Applied Clinical EBM Institute (ACEI), Honolulu, HI, USA. Leading quantitative health services research and evidence synthesis.

2024-Present

DHA Candidate & Principal Investigator

College of Doctoral Studies, Grand Canyon University, Phoenix, AZ / Honolulu, HI, USA.

2026

Joined Scholarly Open

Appointed as Editorial Board Member for Scholarly Open: Medicine.

Submit Your Research to Dr. Lee

Dr. Lee is welcoming original submissions and proposal reviews in healthcare administration, operations and management; health services research; medicine & evidence-based medicine. Submit now to receive high-quality peer review and rapid publication.

Propose Manuscript

Scholarly Open Contributions

Editorial activity and publication history

Active Board Member

Dr. Lee joined our board as a founding Editorial Board Member in 2026.

While the editorial board is actively coordinating upcoming peer reviews, handled manuscripts will appear here once publication rounds conclude.