
Sam Lee, M.D., Ph.D.
College of Doctoral Studies Grand Canyon University, USA
Editorial Vision
"As an Editorial Board Member for Scholarly Open: Medicine, I am dedicated to advancing evidence-based healthcare, health outcomes research, and healthcare quality improvement. I welcome high-impact research evaluating clinical effectiveness, healthcare operations, predictive analytics, and evidence synthesis."
Status
Accepting Submissions
Ready to review manuscripts
Avg. Turnaround
21 Days
From assignment to review completion
Review Standard
Rigorous Double-Blind
Ensuring evidence-based standards
Editorial Mandate
Managed Sections
Biography
Dr. Sam Lee, MD, PhD, DHA Candidate, is an accomplished physician-scientist, healthcare administrator, and evidence-based medicine researcher with over 30 years of clinical, academic, and biomedical research experience across the United States, China, and international healthcare systems. He currently serves as Principal Investigator at Grand Canyon University and is the Founder and Chief EBM Scientist at the Applied Clinical EBM Institute (ACEI) in Honolulu, Hawaii.
Currently a Doctor of Health Administration (DHA) candidate at the College of Doctoral Studies, Grand Canyon University (Phoenix, AZ / Honolulu, HI), Dr. Lee's doctoral research focuses on hospital-level organizational factors associated with risk-standardized mortality rates among U.S. acute care hospitals using publicly available CMS datasets.
Dr. Lee earned his M.D. equivalent and completed surgical specialization at Shanghai Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine (SJTUSM), practicing as a licensed General Surgeon for over ten years. He holds a Master of Science (M.Sc.) and a Ph.D. in Surgery (Medical Sciences) from SJTUSM. He conducted postdoctoral biomedical research as an NIH Postdoctoral Fellow and Research Scholar at the National Institutes of Health (NIH / NICHD / NIAID) in Bethesda, MD, and served as a Research Associate at St. Jude Children's Research Hospital and the University of Tennessee Health Science Center (UTHSC).
His broad research portfolio spans evidence-based medicine (EBM), health services research, quantitative data analysis, healthcare quality improvement, cancer biology, epigenetics, and neurogenomics. Dr. Lee co-discovered Kynurenine Aminotransferase III (KAT III) and pioneered the first publicly searchable RNA-seq transcriptomic dataset for BXD mouse brains in the UCSC Genome Browser.
Selected Publications
Author Name Note:Due to a legal name change, publications appear under his former name ZhengSheng Li and are indexed as Li, Z. or Li, D. Both names refer to the same author.
A transposon in COMT generates mRNA variants and causes widespread expression and behavioral differences among mice
PLoS ONE • 2010
Joint mouse-human phenome-wide association to test gene function and disease risk
Nature Communications • 2016
Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting Topoisomerases
Yeast as a Tool in Cancer Research (Springer) • 2007
A promoter polymorphism in the Per3 gene is associated with alcohol and stress response
Translational Psychiatry • 2012
Academic Roadmap
M.Sc. in Surgery
Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Awarded Outstanding Master's Thesis Award.
Ph.D. in Surgery (Medical Sciences)
Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Awarded Ph.D. Candidate Scholarship & NSFC Grant.
General Surgeon & Assistant Professor
Shanghai Institute of Digestive Surgery, Shanghai Ruijin Hospital. Over 10 years of clinical surgical practice.
NIH Postdoctoral Fellow
National Institutes of Health (NIH), Bethesda, MD, USA. U.S.–China Exchange Scholar in cancer biology and epigenetics.
NIH Research Scholar Fellowship
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA.
Research Associate in Molecular Pharmacology
St. Jude Children's Research Hospital, Memphis, TN, USA. Investigated anticancer agent mechanisms targeting topoisomerases.
Research Associate in Genetics & Neurobiology
University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA. Created BXD mouse brain RNA-seq dataset for UCSC Genome Browser.
Founder & Chief EBM Scientist
Applied Clinical EBM Institute (ACEI), Honolulu, HI, USA. Leading quantitative health services research and evidence synthesis.
DHA Candidate & Principal Investigator
College of Doctoral Studies, Grand Canyon University, Phoenix, AZ / Honolulu, HI, USA.
Joined Scholarly Open
Appointed as Editorial Board Member for Scholarly Open: Medicine.
Submit Your Research to Dr. Lee
Dr. Lee is welcoming original submissions and proposal reviews in healthcare administration, operations and management; health services research; medicine & evidence-based medicine. Submit now to receive high-quality peer review and rapid publication.
Scholarly Open Contributions
Editorial activity and publication history
Dr. Lee joined our board as a founding Editorial Board Member in 2026.
While the editorial board is actively coordinating upcoming peer reviews, handled manuscripts will appear here once publication rounds conclude.